Now the whole country is promoting the original innovation of "from 0 to 1" to improve the level of basic research, but what is "from 0 to 1" and what is "from 1 to N"? Opinions differ, and there is no clear dividing line. After all, the vast majority of research is standing on the shoulders of predecessors' work. Here, I will talk about how our research group started to use neural networks for de novo protein design. I hope to be able to introduce some ideas and discuss with you: what is "from 0 to 1"? How to promote such a primitive Innovation?For details, please check: News link